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Parameter
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Value
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References
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All simulations
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Arteriole diameter
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30 μm
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Iliff [34], Xiong [44], Mestre [16] (40 μm); other modeling studies: Jin [38], Holter [35]
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Venule diameter
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30 μm
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Iliff [34], Xiong [44]; other modeling studies: Jin [38] (40 μm), Holter [35]
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Flow simulations
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Vessel separation (distance between arterioles and venules)
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250 μm
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Nishimura [22] (175 μm rats), Adams [21] (280 μm primates), other modeling studies: Jin [38] (250 μm), Holter [35] (280 μm)
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RTI and clearance simulations
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RTI current
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From appropriate experiment
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Cserr [30], Kress [25], Xie [24]
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Free diffusivity
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As reported for each molecule in “Methods” or “Results”
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Nicholson [14]
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Void volume
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Mean value from appropriate experimental data
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Cserr [30], Kress [25], Xie [24]
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Tortuosity
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Fitted. Increased from experimental mean value to fit RTI data. See “Discussion” of adjusted tortuosity
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Cserr [30], Kress [25], Xie [24]
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Variables
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Value range
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References
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Flow simulations
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Hydraulic conductivity
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2 × 10−6 to 2 × 10−8 cm2 mmHg−1 s−1
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See Table 3
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Pressure at arteriolar PVW
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0.2 to 8 mmHg
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See Table 3
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RTI and clearance simulations
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Bulk flow velocity
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0 to 250 μm min−1
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By adjusting hydraulic conductivity and pressure within above ranges
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PVW diffusivity
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0.6 to 100% of DECS
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Mathiisen [10], Korogod [13], (see “Methods”)
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Vessel separation (distance between arterioles and venules)
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225–275 μm
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Nishimura [22] (175 μm rats), Adams [21] (280 μm primates), other modeling studies: Jin [38] (250 μm), Holter [35] (280 μm)
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- Parameters are held constant; they are either taken from literature or fitted from experimental data. Variables are varied to test different transport hypotheses (see Table 4)
